I was thinking if I sent out my really big monthly email from the noreply address that all of those out of office messages, etc. would end up going to the no reply email address instead of my webmaster address.
However, sometimes I get emails from people that simply say "Unsubscribe" in the message title or the message body because the person either didn't see the unsubscribe link, or they tried the unsubscribe link and it didn't work. (I have a couple of users who said they tried it and it took them to a vbmail page but there were no mailing lists listed on the page to unsubscribe from, not sure if it was their browser or what)
If I used the noreply email then I would never see those manual responses and people might get ticked off they weren't able to unsubscribe in some way. Just a thought... maybe use the webmaster for a couple of more mailings then use the noreply from there on out...